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Curriculum Vitae Georg Heinkele

Research Associate at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart
phone: ++49-711-8101 5901
fax: ++49-711-859295
Georg Heinkele

phone: ++49-711-8101 5901

Education and Professional Career
1987-1991 Study of Chemistry at the university of applied sciences, Reutlingen, Germany
1988 Internship at Sika Chemie, Bad Urach, Germany
1989 Internship at the Laboratory of Analytical Chemistry Dr. Gerhard Wiegleb, Leonberg, Germany
1990 Diploma thesis at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology: Synthesis and structural characterization of Sparteine, its human metabolites and its 17-Deuterioisotopomeres and identification of the main metabolites using [2]H-NMR-Spectroscopy.
1990 Research associate at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Selected References
  • Radke M, Lauwigi C, Heinkele G, Mürdter TE, Letzel M. Fate of the antibiotic sulfamethoxazole and its two major human metabolites in a water sediment test. Environ Sci Technol. 2009 May 1;43(9):3135-41
  • Heinkele G, Mürdter TE. Synthesis of [2H3]-labelled sulfamethoxazole and its main urinary metabolites. J Label Compd Radiopharm 2007; 50(7):656-659
  • Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB, Dorje F, Fromm MF, Konig J. The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug Metab Dispos. 2007 May; 35(5):779-86.
  • Foster DJ, Morton EB, Heinkele G, Murdter TE, Somogyi AA. Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject. Ther Drug Monit. 2006 Aug;28(4):559-67
  • Heinkele G, Mürdter TE. Synthesis of [2H]-labelled phase-I-metabolites using 1-[2H]-pyridinium hydrochloride. J Label Compd Radiopharm 2005; 48(6):457-461
  • Heinkele G, Schänzle G, Mürdter TE. Synthesis of [2H3]-dextromethorphan and its major urinary metabolites [2H3]-dextrorphan and [2H3]-dextrorphan ß-glucuronide. J Label Compd Radiopharm 2002; 45(13):1153-1158
  • Heinkele G, Hofmann U, Opitz J, Mürdter TE. Synthesis of 2H-Labelled Dihydropyrimidinediones and their Metabolites. J Label Compd Radiopharm 2001; 44(1):7-11
  • Heinkele G, Nussbaum R, Fischer P, Kroemer H, Meese CO. A regioselectively labelled reagent for the Koenigs-Knorr synthesis of deuterated drug conjugates. Isotopenpraxis Environ. Health. Stud. 1994, Vol. 30, pp.213-214
  • Meese CO, Eichelbaum M, Ebner T, Heinkele G, Krimmer S, Fischer P. 13C and 2H NMR as ex-vivo probe for human drug metabolism. Synthesis and Applications of Isotopically Labelled Compounds 1991; E.Buncel and G.W Kabalka (Editors); 1992 Elsevier Science Publisher B.V. pp. 291 – 296