Membrane Transport Proteins and Pharmacogenomics
Transporters play critical roles in the absorption, disposition, and elimination of numerous drugs that are in clinical use. Alterations in the expression and function of these transporters may significantly contribute to drug pharmacokinetics and the interindividual variability of drug response. Our research aims to unravel genetic and non-genetic factors that affect transporter expression and function. The long-term goal is to explore the impact of transporter Pharmacogenomics in disease cohorts already available at the Institute of Clinical Pharmacology.
Major Projects
- Molecular cell biology of drug transporters
- Functional characterization of drug transporters
- Pharmacogenomics of drug transporters
Prof. Dr. Anne Nies
phone: ++49-711-8101 3729
Selected References
- Drenberg C, Gibson AA, Pounds S, Shi L, Rhinehart D, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A. OCTN1 is a high-affinity carrier of nucleoside analogs. Cancer Res (2017) Apr 15;77:2102-2111.
- Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT. Impact of membrane drug transporters to resistance of small molecule tyrosine kinase inhibitors. Trends Pharmacol Sci (2016);37:904-932
- Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M. Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine. Arch Toxicol (2016);90:1555-1584
- Emami Riedmaier A, Burk O, van Eijck BAC, Schaeffeler E, Müller S, Winter S, Zanger UM, Schwab M, Nies AT. Organic anion transporter 7: a novel pravastatin uptake transporter in human liver regulated by hepatocyte nuclear factor 4-alpha. Pharmacogenomics J (2016); 16:341-351.
- Arlanov R, Lang T, Jedlitschky G, Schaeffeler E, Ishikawa T, Schwab M, Nies AT. Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally-damaging variant. Pharmacogenomics J (2016); 16(2):193-201.
- Nies AT, Magdy T, Schwab M, Zanger UM. Role of ABC transporters in fluoropyrimidine-based chemotherapy response. Adv Cancer Res (2015);125:217-243
- Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT. Impact of genetic polymorphisms of ABCB1 (MDR1, P-glycoprotein) on drug disposition and potential clinical implications: update of the literature. Clin Pharmacokinet (2015);54:709-735
- Emami Riedmaier A, Fisel P, Nies AT, Schaeffeler E, Schwab M. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol Sci (2013);34:126-135
- Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SCL22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50, 1227-1240.
Curriculum Vitae Anne Nies, PhD
Affiliation
Head Membrane Transport Proteins
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstrasse 112
70376 Stuttgart Germany
phone: ++49-711-8101 3729
fax: ++49-711-859295
email: anne.nies@ikp-stuttgart.de
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
Auerbachstrasse 112
70376 Stuttgart Germany
phone: ++49-711-8101 3729
fax: ++49-711-859295
email: anne.nies@ikp-stuttgart.de
Education and Professional Career
1984-1990 | Studies of Biology, University of Düsseldorf, Germany |
1990 | Diploma in Biology, University of Düsseldorf |
1990-1993 | PhD thesis in Biology, University of Düsseldorf |
1993 | Dr. rer. nat. (Ph.D.) in Biology, University of Düsseldorf, on transport and metabolism of urate in the hepatopancreas of the lobster |
1994-1996 | Postdoctoral Research Fellow of the Deutsche Forschungsgemeinschaft at Tufts University, Department of Physiology (Boston, MA, USA), on the biochemistry und molecular biology of P-glycoprotein and other hepatic transport systems |
1996-2007 | Senior Research Scientist at the German Cancer Research Center, Division of Tumor Biochemistry, Heidelberg, Germany. Research area: Molecular cell biology of ATP-dependent efflux pumps and uptake transporters in the plasma membrane |
2004 | Habilitation and venia legendi in Biochemistry, University of Heidelberg Medical School |
Since 2007 | Senior Group Leader and Head of Membrane Transport Proteins, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany |
Since 2008 | Venia legendi in Biochemical Pharmacology, University of Tübingen Medical School, Germany |
2014 | Extraordinary professorship at the University of Tübingen Medical School |