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Dr. Ute Hofmann

phone: ++49-711-8101 5907

Major Projects
  • Mass spectrometry-based targeted metabolomics and lipidomics
  • Drug metabolism
  • Development of analytical methods
Selected References
  • Burk O, Brenner SS, Hofmann U, Tegude H, Igel S, Schwab M, Eichelbaum M, Alscher MD. The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin. Clin Pharmacol Ther 2010;88(5):685-94
  • Feidt DM, Klein K, Hofmann U, Riedmaier S, Knobeloch D, Thasler WE, Weiss TS, Schwab M, Zanger UM: Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using A New LC-MS/MS Cocktail Assay in Human Hepatocytes. Drug Metab Dispos 2010;38(9):1589-97
  • Maier K, Hofmann U, Reuss M, Mauch K. Dynamics and control of the central carbon metabolism in hepatoma cells. BMC Systems Biology 2010; 4:54
  • Riedmaier S, Klein K, Hofmann U, Keskitalo JE, Neuvonen PJ, Schwab M, Niemi M, Zanger UM. UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo. Clin Pharmacol Ther. 2010;87(1):65-73.
  • Karner S, Shi S, Fischer C, Schaeffeler E, Neurath MF, Herrlinger KR, Hofmann U, Schwab M. Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? Ther Drug Monit.2010;32(2):119-28.
  • Maier K, Hofmann U, Bauer A, Niebel A, Vacun G, Reuss M, Mauch K. Quantification of statin effects on hepatic cholesterol synthesis by transient 13C flux analysis. Metab Eng. 2009;11(4-5):292-309.
  • Birkenfeld AL, Jordan J, Hofmann U, Busjahn A, Franke G, Krüger N, Igel S, Mürdter T, Drescher S, Shi S, Engeli S, Schwab M, Eichelbaum M, Luft FC, Fromm MF. Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins. Clin Pharmacol Ther. 2009;86(6):605-8.
  • Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M; German 5-FU Toxicity Study Group. Role of genetic and nongenetic factors for fluorouracil reatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008;26(13):2131-8.
  • Hofmann U, Maier K, Niebel A, Vacun G, Reuss M, Mauch K. Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations. Biotechnol Bioeng. 2008;100(2):344-54.
  • Maier K, Hofmann U, Reuss M, Mauch K. Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol Bioeng. 2008;100(2):355-70.
Major Networks and Collaborations
  • Member of LiSym (Liver Systems Medicine) funded by the BMBF
Extramural Funding
  • BMBF (Federal Ministry of Education and Research) Virtual Liver Network for systems biology of the liver

 

Curriculum Vitae Ute Hofmann, PhD

Affiliation
Head of Analytical Chemistry and Synthesis

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
70376 Stuttgart Germany
phone: ++49-711-81015907
fax: ++49-711-859295
email: ute.hofmann@ikp-stuttgart.de
Education and Professional Career
1977–1984 Studies in chemistry, University of Stuttgart, Stuttgart, Germany
1984–1986 Ph.D. at the Institute of Organic Chemistry, University of Stuttgart, under supervision of Prof. P. Fischer
since 2/1987 Scientist at the Dr. Margarete Fischer-Bosch-Institute for Clinical Pharmacology, Stuttgart
since 6/1992 Head of the Department of Analytical Chemistry at the Dr. Margarete Fischer-Bosch-Institute