Staff

Curriculum Vitae Meng Dong, PhD

Affiliation

Postdoctoral fellow at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart
phone: ++49-711-8101 2070
fax: ++49-711-859295
email: meng.dong@ikp-stuttgart.de

Dr. rer. nat. Meng Dong

phone: ++49-711-8101 3758

meng.dong@ikp-stuttgart.de

Education and Professional Career

1998-2003	Bachelor of Medical Science, West China Medical Center of Sichuan University, China
2004-2006	M.Sc. of Molecular Bioengineering, TU Dresden, Germany
2007-2011	PhD at Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen with cooperation of Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Germany
2011-present	Postdoctoral fellow at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Germany Research Area: Tissue slice culture as preclinical models for personalized medicine

Selected References

Fuentes-Chandía, Miguel; Vierling, Andreas; Kappelmann-Fenzl, Melanie; Monavari, Mahshid; Letort, Gaelle; Höne, Lucas et al. (2021): 3D Spheroids Versus 3D Tumor-Like Microcapsules. Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells. In: Advanced biology 5 (7), e2000349. DOI: 10.1002/adbi.20200034 (FREE ARTICLE)

Kleih M, Böpple K, Dong M, Gaißler A, Heine S, Olayioye MA, Aulitzky WE, Essmann F. Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death Dis. 2019 Nov 7;10(11):851. doi: 10.1038/s41419-019-2081-4. (FREE ARTICLE)

de Hoogt R, Estrada MF,Vidic S, Davies EJ, Osswald A, Barbier M, Santo VE, Gjerde K, van Zoggel HJ,Blom S, Dong M, Närhi K, Boghaert E, Brito C, Chong Y, Sommergruber W, van der Kuip H, van Weerden WM, Verschuren EW, Hickman J, Graeser R. Protocols and characterization data for 2D, 3D,and slice-based tumor models from the PREDECT project. Sci Data. 2017 Nov 21;4:170170. doi: 10.1038/sdata.2017.170. (FREE ARTICLE)

Davies EJ, Dong M, Gutekunst M, Närhi K, van Zoggel HJ etal. Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices. Sci Rep. 2015 Dec 9;5:17187 (FREE ARTICLE)

Rudisch A, Dewhurst MR, Horga LG, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W. High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts. PLoS One. 2015 Apr 28;10(4):e0124283. (FREE ARTICLE)

Schmid JO, Dong M, Haubeiss S, Friedel G, Bode S, Grabner A, Ott G, Mürdter TE, Oren M, Aulitzky WE, van der Kuip H. Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin. Cancer Res. 2012 Nov 15;72(22):5824-32. (FREE ARTICLE)

Dong M, Mürdter TE, Philippi C, Loretz B, Schaefer UF, Lehr CM, Schwab M, Ammon-Treiber S. Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung. Eur J Pharm Biopharm. 2012 Aug;81(3):478-85. doi: 10.1016/j.ejpb.2012.04.022.
Dong M, Philippi C, Loretz B, Nafee N, Schaefer UF, Friedel G, Ammon-Treiber S, Griese EU, Lehr CM, Klotz U, Mürdter TE. Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2´-O-methyl-RNA. Int J Pharm.2011 Oct 31;419(1-2):33-42

Dong M, Mürdter TE, Klotz U. Telomeres and telomerase as novel drug targets: reflections on the 2009 Nobel Prize in Physiology or Medicine. Eur J Clin Pharmacol. 2010 Jan; 66(1):1-3. (FREE ARTICLE)

Beisner J, Dong M, Taetz S, Nafee N, Griese EU, Schaefer UF, Lehr CM, Klotz U, Mürdter TE. Nanoparticle mediated delivery of 2'-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells. Lung Cancer. 2010 Jun; 68(3):346-54.
Beisner J, Dong M, Taetz S, Piotrowska K, Kleideiter E, Friedel G, Schaefer UF, Lehr CM, Klotz U, Mürdter TE. Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2'-O-methyl-RNA. J Pharm Sci. 2009 May; 98(5):1765-74.