Staff

Curriculum Vitae Roman Tremmel

Affiliation

Scientist at the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart
phone: ++49-711-8101 2061
fax: ++49-711-859295
email: roman.tremmel@ikp-stuttgart.de
github: https://github.com/roman-tremmel
ORCID ID: https://orcid.org/0000-0003-1564-0433

Roman Tremmel

phone: ++49-711-8101-2061

roman.tremmel@ikp-stuttgart.de

Education and Professional Career

2005-2011	Studies in Biology at the University of Hohenheim, Stuttgart, Germany
2011	Diploma thesis in the Institute of Genetics at the University of Hohenheim, Stuttgart, Germany (Prof. Dr. rer. nat. Anette Preiss). “Komplementärmutation in Notch und Suppressor of Hairless zur Analyse exogener Su(H)-Aktivität”
2016	PhD thesis (Prof. Dr. U.M. Zanger) “ Bioinformatische Analyse und funktionelle Charakterisierung von strukturellen Genvarianten in ADME-Genen in humaner Leber”
Since 2015	Scientist (Prof. Dr. M. Schwab) at the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology.

Selected References

Tremmel, Roman; Klein, Kathrin; Battke, Florian; Fehr, Sarah; Winter, Stefan; Scheurenbrand, Tim et al. (2020): Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression. In Human genetics 139 (2), pp. 137–149. DOI: 10.1007/s00439-019-02093-7. (FREE ARTICLE)

Abdel-Kahaar, Emaad; Winter, Stefan; Tremmel, Roman; Schaeffeler, Elke; Olbricht, Christoph J.; Wieland, Eberhard et al. (2019): The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center. In Front. Genet. 10, p. 871. DOI: 10.3389/fgene.2019.00871. (FREE ARTICLE)

Klein, Kathrin; Tremmel, Roman; Winter, Stefan; Fehr, Sarah; Battke, Florian; Scheurenbrand, Tim et al. (2019): A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. In Front. Genet. 10, p. 56. DOI: 10.3389/fgene.2019.00007. (FREE ARTICLE)

Florian, Anca; Patrascu, Alexandru; Tremmel, Roman; Rösch, Sabine; Sechtem, Udo; Schwab, Matthias et al. (2018): Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Approach. In Frontiers in physiology 9, p. 1770. DOI: 10.3389/fphys.2018.01770. (FREE ARTICLE)

Schärfe, Charlotta Pauline Irmgard; Tremmel, Roman; Schwab, Matthias; Kohlbacher, Oliver; Marks, Debora Susan (2017): Genetic variation in human drug-related genes. In Genome Med 9 (1), p. 1818. DOI: 10.1186/s13073-017-0502-5. (FREE ARTICLE)

Tamm, R.; Mägi, R.; Tremmel, R.; Winter, S.; Mihailov, E.; Smid, A. et al. (2017): Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype. A Meta-Analysis of Three Genome-Wide Association Studies. In Clin. Pharmacol. Ther. 101 (5), pp. 684–695. DOI: 10.1002/cpt.540. (FREE ARTICLE)

Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM (2017) Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels. Arch Toxicol. doi: 10.1007/s00204-017-1955-4 (FREE ARTICLE)

Tremmel, R.; Klein, K.; Winter, S.; Schaeffeler, E.; Zanger, U. M. (2016): Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1. In Pharmacogenomics J 16 (6), pp. 551–558. DOI: 10.1038/tpj.2015.69

Worst, Barbara C.; van Tilburg, Cornelis M.; Balasubramanian, Gnana Prakash; Fiesel, Petra; Witt, Ruth; Freitag, Angelika et al. (2016): Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. In European journal of cancer (Oxford, England : 1990) 65, pp. 91–101. DOI: 10.1016/j.ejca.2016.06.009. (FREE ARTICLE)

See all of my publications at https://scholar.google.com/citations?user=-5BC9nwAAAAJ&hl=de or https://loop.frontiersin.org/people/649624/overview

Major Projects

Pharmacogenetics and genomics
Implementation of pharmacogenetics testing in the clinics