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Curriculum Vitae Frank Essmann

Group leader at the Dr. Margarete Fischer-Bosch – Institute of Clinical Pharmacology

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart
phone: ++49-711-8101 5755
fax: ++49-711-859295
PD Dr. Frank Essmann

phone: ++49-711-8101 5755

Professional Education and Career
1992-1997 Studies in chemistry at the University of Dortmund, Germany
1997 Diploma thesis at the Max-Planck-Institute for Molecular Physiology and Diploma in chemistry
1997-1999 PhD thesis: “Mechanisms of Apoptosis in Cancer: Regulatory Role of Caspases” at the Charité / Humboldt University Berlin (Prof. P.T. Daniel) and Max-Delbrück-Centrum (MDC) (Prof. B. Wittmann-Liebold)
1999-2001 Post-doctoral scientist at the Charité / Humboldt University Berlin
2001-2002 Startup Co-Founder at Proteome Factory AG
2002-2008 Junior group leader at the Institute for Molecular Medicine / Heinrich Heine University Düsseldorf (Prof. K. Schulze-Osthoff)
2008 Habilitation in Molecular Medicine at the Heinrich Heine University Düsseldorf. „Regulationsebenen der Apoptose: Vom DNA-Schaden zur Proteinspaltung.“
2008-2018 Group leader at the Dept of Molecular Medicine (Prof. K. Schulze-Osthoff) / Eberhard-Karls-University Tübingen, Germany
Since 10/2018 Group leader at the Dr. Margarete Fischer-Bosch – Institute of Clinical Pharmacology, Stuttgart, Germany
Selected References
  • Dose A, Sindlinger J, Bierlmeier J, Bakirbas A, Schulze-Osthoff K, Einsele-Scholz S, Hartl M, Essmann F, Finkemeier I, Schwarzer D. (2016). Interrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical Probes. Angew Chem Int Ed Engl 55(3):1192-5
  • Zhang Y, Mu J, Essmann F, Feng Y, Kramer M, Bao HY, Grond S (2015). A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP2T1. Nat Prod Res (17):1-5
  • Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R (2014). Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res 115(7):662-7
  • Konantz M, André MC, Ebinger M, Grauer M, Wang H, Grzywna S, Rothfuss OC, Lehle S, Kustikova OS, Salih HR, Handgretinger R, Fend F, Baum C, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C (2012). EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia. Leukemia 27(1):56-65
  • Weiland T, Berger A, Essmann F, Lauer U, Bitzer M, Venturelli S (2012). Kinetic tracking of therapy induced senescence using the Real-Time Cell Analyzer SP system. ASSAY and Drug Development Technologies 10(3):289-95
Major Projects
  • tumor biology / signal transduction
  • apoptosis / Bcl-2 protein family / mitochondria
  • senescence / epigenetics
  • immunology