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Anti-hormone Drug Metabolism and Pharmacodynamics

Dr. Thomas Mürdter

phone: ++49-711-8101 5974

Major Projects
  • Influence of pharmacogenetics on the metabolism of Selective Estrogen Receptor Modulators
  • Synthesis and analysis of phase I and II metabolites
  • Ex vivo models of human tumors
Selected References
  • Schaaf L, Schwab M, Ulmer C, Heine S, Mürdter TE, Schmid JO, Sauer G, Aulitzky WE, van der Kuip H. Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. Cancer Res. 2016 May 15;76(10):2868-75.
Major Networks and Collaborations
  • TAMENDOX: Genotype and phenotype guided supplementation of TAMoxifen standard therapy with ENDOXifen in breast cancer patients
Extramural Funding
  • BMBF (Federal Ministry of Education and Research): Initiative Individualized Medicine: TAMENDOX
  • DFG (German Research Foundation): The role of agonistic metabolites in Tamoxifen resistance

Curriculum Vitae Thomas Mürdter, PhD

Affiliation
Deputy Head at the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP), Stuttgart, Germany
Research Group Leader Drug Sensitivity and Disease / Tumor Models

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstr. 112
D-70376 Stuttgart Germany
phone: ++49-711-8101 5974
fax: ++49-711-859295
email: thomas.muerdter@ikp-stuttgart.de
Education and Professional Career
Since 1997 Scientist at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
1997 PhD in Chemistry. Thesis: Distribution, tumour selectivity, and bio-activation of doxorubicin in the isolated perfused human lung model.
1994-1997 PhD studies at Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
1992-1994 Deputy head of the Department of Polymer and Environmental Analysis at the Institute of Polymeric Sciences, Stuttgart, Germany
1991-1992 Research fellow at the Fraunhofer Institute for Interfacial Engineering and Biotechnology
1991 Diploma Thesis at the Department of Chemical Microbiology at the Fraunhofer Institute for Interfacial Engineering and Biotechnology: Degradation of trichloroethylene by the alcaligenes denitrificans ssp xylosoxidans strain JE95
1988-1991 Graduate studies in Chemistry with elective subject Biochemistry at University of Stuttgart
1988 Industrial traineeship at PLIVA Ltd. Zagreb, Yugoslavia
1984-1987 Undergraduate studies in Chemistry at University of Stuttgart
Professional Memberships
Since 1998: Member of the DGTP (German Society of Toxicology and Pharmacology)